Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

BACKGROUND: The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties. MATERIALS AND M...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Karlsson, Henning, Fryknäs, Mårten, Strese, Sara, Gullbo, Joachim, Westman, Gunnar, Bremberg, Ulf, Sjöblom, Tobias, Pandzic, Tatjana, Larsson, Rolf, Nygren, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444738/
https://ncbi.nlm.nih.gov/pubmed/28415818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16324
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