Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

Although cisplatin has played a role in “standard-of-care” multimodality therapy for patients with advanced squamous cell carcinoma of the head and neck (HNSCC), the rate of treatment failure remains particularly high for patients receiving cisplatin whose tumors have mutations in the TP53 gene. We...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cancer Ther
Egile Nagusiak: Osman, Abdullah A., Monroe, Marcus M., Ortega Alves, Marcus V., Patel, Ameeta A., Katsonis, Panagiotis, Fitzgerald, Alison L., Neskey, David M., Frederick, Mitchell J., Woo, Sang Hyeok, Caulin, Carlos, Hsu, Teng-Kuei, McDonald, Thomas O., Kimmel, Marek, Meyn, Raymond E., Lichtarge, Olivier, Myers, Jeffrey N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557970/
https://ncbi.nlm.nih.gov/pubmed/25504633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0735-T
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