Wee-1 Kinase Inhibition Overcomes Cisplatin Resistance Associated with High-Risk TP53 Mutations in Head and Neck Cancer through Mitotic Arrest Followed by Senescence

Although cisplatin has played a role in “standard-of-care” multimodality therapy for patients with advanced squamous cell carcinoma of the head and neck (HNSCC), the rate of treatment failure remains particularly high for patients receiving cisplatin whose tumors have mutations in the TP53 gene. We...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cancer Ther
Prif Awduron: Osman, Abdullah A., Monroe, Marcus M., Ortega Alves, Marcus V., Patel, Ameeta A., Katsonis, Panagiotis, Fitzgerald, Alison L., Neskey, David M., Frederick, Mitchell J., Woo, Sang Hyeok, Caulin, Carlos, Hsu, Teng-Kuei, McDonald, Thomas O., Kimmel, Marek, Meyn, Raymond E., Lichtarge, Olivier, Myers, Jeffrey N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557970/
https://ncbi.nlm.nih.gov/pubmed/25504633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0735-T
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