Evolutionary Action score of TP53 (EAp53) identifies high risk mutations associated with decreased survival and increased distant metastases in head and neck cancer

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC) with mutations occurring in over two third of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational approach termed Evolutionary Act...

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Foilsithe in:Cancer Res
Main Authors: Neskey, David M., Osman, Abdullah A., Ow, Thomas J., Katsonis, Panagiotis, McDonald, Thomas, Hicks, Stephanie C., Hsu, Teng-Kuei, Pickering, Curtis R., Ward, Alexandra, Patel, Ameeta, Yordy, John S., Skinner, Heath D., Giri, Uma, Sano, Daisuke, Story, Michael D., Beadle, Beth M., El-Naggar, Adel K., Kies, Merrill S., William, William N., Caulin, Carlos, Frederick, Mitchell, Kimmel, Marek, Myers, Jeffrey N., Lichtarge, Olivier
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383697/
https://ncbi.nlm.nih.gov/pubmed/25634208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2735
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