TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence

PURPOSE: Mortality of patients with head and neck squamous cell carcinoma (HNSCC) is primarily driven by tumor cell radioresistance leading to locoregional recurrence (LRR). In this study, we use a classification of TP53 mutation (disruptive vs. nondisruptive) and examine impact on clinical outcomes...

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Auteurs principaux: Skinner, Heath D., Sandulache, Vlad C., Ow, Thomas J., Meyn, Raymond E., Yordy, John S., Beadle, Beth M., Fitzgerald, Alison L., Giri, Uma, Ang, K. Kian, Myers, Jeffrey N.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251726/
https://ncbi.nlm.nih.gov/pubmed/22090360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2260
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