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Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status

BACKGROUND: Mutations in the TP53 tumor suppressor gene are common in HNSCC and correlate with radioresistance. Currently, there are no clinically available therapeutic approaches targeting p53 in HNSCC. Here we propose a strategy which uses TP53 mutational status to individualize anti-metabolic str...

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Detalhes bibliográficos
Main Authors: Sandulache, Vlad C., Skinner, Heath D., Ow, Thomas J., Zhang, Aijun, Xia, Xuefeng, Luchak, James M., Wong, Lee-Jun C., Pickering, Curtis R., Zhou, Ge, Myers, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188683/
https://ncbi.nlm.nih.gov/pubmed/21720999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26321
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