Disruptive TP53 Mutation is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer

PURPOSE: To characterize tumor growth and metastatic potential in head and neck squamous cell carcinoma (HNSCC) cell lines in an orthotopic murine model of oral tongue cancer, and to correlate TP53 mutation status with these findings. EXPERIMENTAL DESIGN: Cells from each of 48 HNSCC cell lines were...

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Main Authors: Sano, Daisuke, Xie, Tong-Xin, Ow, Thomas J., Zhao, Mei, Pickering, Curtis R., Zhou, Ge, Sandulache, Vlad C., Wheeler, David A., Gibbs, Richard A., Caulin, Carlos, Myers, Jeffrey N.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207013/
https://ncbi.nlm.nih.gov/pubmed/21903770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0046
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