Evolutionary Action score of TP53 (EAp53) identifies high risk mutations associated with decreased survival and increased distant metastases in head and neck cancer

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC) with mutations occurring in over two third of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational approach termed Evolutionary Act...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cancer Res
Autors principals: Neskey, David M., Osman, Abdullah A., Ow, Thomas J., Katsonis, Panagiotis, McDonald, Thomas, Hicks, Stephanie C., Hsu, Teng-Kuei, Pickering, Curtis R., Ward, Alexandra, Patel, Ameeta, Yordy, John S., Skinner, Heath D., Giri, Uma, Sano, Daisuke, Story, Michael D., Beadle, Beth M., El-Naggar, Adel K., Kies, Merrill S., William, William N., Caulin, Carlos, Frederick, Mitchell, Kimmel, Marek, Myers, Jeffrey N., Lichtarge, Olivier
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383697/
https://ncbi.nlm.nih.gov/pubmed/25634208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2735
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars