Evolutionary Action Score of TP53 Coding Variants (EAp53) is Predictive of Platinum Response in Head and Neck Cancer Patients

TP53 is the most frequently altered gene in head and neck squamous cell carcinoma (HNSCC) with mutations occurring in over two third of cases, however, the predictive response of these mutations to cisplatin based therapy remains elusive. In the current study, we evaluate the ability of the Evolutio...

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Publicado no:Cancer Res
Main Authors: Osman, Abdullah A., Neskey, David M., Katsonis, Panagiotis, Patel, Ameeta A., Ward, Alexandra M., Hsu, Teng-Kuei, Hicks, Stephanie C., McDonald, Thomas O., Ow, Thomas J., Alves, Marcus Ortega, Pickering, Curtis R., Skinner, Heath D., Zhao, Mei, Sturgis, Eric M., Kies, Merrill S., El-Naggar, Adel, Perrone, Federica, Licitra, Lisa, Bossi, Paolo, Kimmel, Marek, Frederick, Mitchell J., Lichtarge, Olivier, Myers, Jeffrey N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615655/
https://ncbi.nlm.nih.gov/pubmed/25691460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2729
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