Survival analysis: coping with non proportional hazards in randomized trials

le Royston, Patrick, Parmar, Mahesh KB
Foilsithe 2011

Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

le Royston, Patrick, Parmar, Mahesh KB
Foilsithe 2013

An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

le Royston, Patrick, Parmar, Mahesh KB
Foilsithe 2014

The need for a cultural shift from two-arm to multi-arm RCTS

le Sydes, Matthew R, Parmar, Mahesh KB
Foilsithe 2013

Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated

le Royston, Patrick, Parmar, Mahesh K.B.
Foilsithe in BMC Med Res Methodol (2016)

A new measure of predictive ability for survival models

le Choodari-Oskooei, Babak, Royston, Patrick, Parmar, Mahesh KB
Foilsithe 2011

Discrimination-based sample size calculations for multivariable prognostic models for time-to-event data

le Jinks, Rachel C., Royston, Patrick, Parmar, Mahesh KB
Foilsithe in BMC Med Res Methodol (2015)

Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework

le Blenkinsop, Alexandra, Parmar, Mahesh KB, Choodari-Oskooei, Babak
Foilsithe in Clin Trials (2019)

A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis

le Bratton, Daniel J, Phillips, Patrick PJ, Parmar, Mahesh KB
Foilsithe 2013

The extension of total gain (TG) statistic in survival models: properties and applications

le Choodari-Oskooei, Babak, Royston, Patrick, Parmar, Mahesh K.B.
Foilsithe in BMC Med Res Methodol (2015)

Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

le Choodari-Oskooei, Babak, Parmar, Mahesh KB, Royston, Patrick, Bowden, Jack
Foilsithe 2013

Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson’s Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer

le Zeissler, Marie-Louise, Li, Vivien, Parmar, Mahesh K.B., Carroll, Camille Buchholz
Foilsithe in J Parkinsons Dis (2020)

Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

le Royston, Patrick, Barthel, Friederike M-S, Parmar, Mahesh KB, Choodari-Oskooei, Babak, Isham, Valerie
Foilsithe 2011

The DURATIONS randomised trial design: Estimation targets, analysis methods and operating characteristics

le Quartagno, Matteo, Carpenter, James R, Walker, A Sarah, Clements, Michelle, Parmar, Mahesh KB
Foilsithe in Clin Trials (2020)

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled...

le Dearnaley, David P, Mason, Malcolm D, Parmar, Mahesh KB, Sanders, Karen, Sydes, Matthew R
Foilsithe 2009

Rethinking non-inferiority: a practical trial design for optimising treatment duration

le Quartagno, Matteo, Walker, A Sarah, Carpenter, James R, Phillips, Patrick PJ, Parmar, Mahesh KB
Foilsithe in Clin Trials (2018)

When should factorial designs be used for late-phase randomised controlled trials?

le White, Ian R, Szubert, Alexander J, Choodari-Oskooei, Babak, Walker, A Sarah, Parmar, Mahesh KB
Foilsithe in Clin Trials (2023)

Sharing data from clinical trials: the rationale for a controlled access approach

le Sydes, Matthew R, Johnson, Anthony L, Meredith, Sarah K, Rauchenberger, Mary, South, Annabelle, Parmar, Mahesh KB
Foilsithe in Trials (2015)

Adding new experimental arms to randomised clinical trials: Impact on error rates

le Choodari-Oskooei, Babak, Bratton, Daniel J, Gannon, Melissa R, Meade, Angela M, Sydes, Matthew R, Parmar, Mahesh KB
Foilsithe in Clin Trials (2020)

Postoperative radiotherapy for non‐small cell lung cancer

le Burdett, Sarah, Rydzewska, Larysa, Tierney, Jayne, Fisher, David, Parmar, Mahesh KB, Arriagada, Rodrigo, Pignon, Jean Pierre, Le Pechoux, Cecile
Foilsithe in Cochrane Database Syst Rev (2016)