Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

BACKGROUND: The pace of novel medical treatments and approaches to therapy has accelerated in recent years. Unfortunately, many potential therapeutic advances do not fulfil their promise when subjected to randomized controlled trials. It is therefore highly desirable to speed up the process of evalu...

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Bibliografiska uppgifter
Huvudupphovsmän: Royston, Patrick, Barthel, Friederike M-S, Parmar, Mahesh KB, Choodari-Oskooei, Babak, Isham, Valerie
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2011
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078872/
https://ncbi.nlm.nih.gov/pubmed/21418571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-12-81
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