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Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework

BACKGROUND: The multi-arm multi-stage framework uses intermediate outcomes to assess lack-of-benefit of research arms at interim stages in randomised trials with time-to-event outcomes. However, the design lacks formal methods to evaluate early evidence of overwhelming efficacy on the definitive out...

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發表在:Clin Trials
Main Authors: Blenkinsop, Alexandra, Parmar, Mahesh KB, Choodari-Oskooei, Babak
格式: Artigo
語言:Inglês
出版: SAGE Publications 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442021/
https://ncbi.nlm.nih.gov/pubmed/30648428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774518823551
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