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Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework
BACKGROUND: The multi-arm multi-stage framework uses intermediate outcomes to assess lack-of-benefit of research arms at interim stages in randomised trials with time-to-event outcomes. However, the design lacks formal methods to evaluate early evidence of overwhelming efficacy on the definitive out...
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| 發表在: | Clin Trials |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
SAGE Publications
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442021/ https://ncbi.nlm.nih.gov/pubmed/30648428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774518823551 |
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