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Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated
BACKGROUND: Most randomized controlled trials with a time-to-event outcome are designed assuming proportional hazards (PH) of the treatment effect. The sample size calculation is based on a logrank test. However, non-proportional hazards are increasingly common. At analysis, the estimated hazards ra...
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| Publicado no: | BMC Med Res Methodol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4751641/ https://ncbi.nlm.nih.gov/pubmed/26869168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-016-0110-x |
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