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An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect
BACKGROUND: Most randomized controlled trials with a time-to-event outcome are designed and analysed under the proportional hazards assumption, with a target hazard ratio for the treatment effect in mind. However, the hazards may be non-proportional. We address how to design a trial under such condi...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BioMed Central
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4133607/ https://ncbi.nlm.nih.gov/pubmed/25098243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6215-15-314 |
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