Survival analysis: coping with non proportional hazards in randomized trials

by Royston, Patrick, Parmar, Mahesh KB
Published 2011

Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome

by Royston, Patrick, Parmar, Mahesh KB
Published 2013

An approach to trial design and analysis in the era of non-proportional hazards of the treatment effect

by Royston, Patrick, Parmar, Mahesh KB
Published 2014

The need for a cultural shift from two-arm to multi-arm RCTS

by Sydes, Matthew R, Parmar, Mahesh KB
Published 2013

Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated

by Royston, Patrick, Parmar, Mahesh K.B.
Published in BMC Med Res Methodol (2016)

A new measure of predictive ability for survival models

by Choodari-Oskooei, Babak, Royston, Patrick, Parmar, Mahesh KB
Published 2011

Discrimination-based sample size calculations for multivariable prognostic models for time-to-event data

by Jinks, Rachel C., Royston, Patrick, Parmar, Mahesh KB
Published in BMC Med Res Methodol (2015)

Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework

by Blenkinsop, Alexandra, Parmar, Mahesh KB, Choodari-Oskooei, Babak
Published in Clin Trials (2019)

A multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosis

by Bratton, Daniel J, Phillips, Patrick PJ, Parmar, Mahesh KB
Published 2013

The extension of total gain (TG) statistic in survival models: properties and applications

by Choodari-Oskooei, Babak, Royston, Patrick, Parmar, Mahesh K.B.
Published in BMC Med Res Methodol (2015)

Impact of lack-of-benefit stopping rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

by Choodari-Oskooei, Babak, Parmar, Mahesh KB, Royston, Patrick, Bowden, Jack
Published 2013

Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson’s Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer

by Zeissler, Marie-Louise, Li, Vivien, Parmar, Mahesh K.B., Carroll, Camille Buchholz
Published in J Parkinsons Dis (2020)

Designs for clinical trials with time-to-event outcomes based on stopping guidelines for lack of benefit

by Royston, Patrick, Barthel, Friederike M-S, Parmar, Mahesh KB, Choodari-Oskooei, Babak, Isham, Valerie
Published 2011

The DURATIONS randomised trial design: Estimation targets, analysis methods and operating characteristics

by Quartagno, Matteo, Carpenter, James R, Walker, A Sarah, Clements, Michelle, Parmar, Mahesh KB
Published in Clin Trials (2020)

Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled...

by Dearnaley, David P, Mason, Malcolm D, Parmar, Mahesh KB, Sanders, Karen, Sydes, Matthew R
Published 2009

Rethinking non-inferiority: a practical trial design for optimising treatment duration

by Quartagno, Matteo, Walker, A Sarah, Carpenter, James R, Phillips, Patrick PJ, Parmar, Mahesh KB
Published in Clin Trials (2018)

When should factorial designs be used for late-phase randomised controlled trials?

by White, Ian R, Szubert, Alexander J, Choodari-Oskooei, Babak, Walker, A Sarah, Parmar, Mahesh KB
Published in Clin Trials (2023)

Sharing data from clinical trials: the rationale for a controlled access approach

by Sydes, Matthew R, Johnson, Anthony L, Meredith, Sarah K, Rauchenberger, Mary, South, Annabelle, Parmar, Mahesh KB
Published in Trials (2015)

Adding new experimental arms to randomised clinical trials: Impact on error rates

by Choodari-Oskooei, Babak, Bratton, Daniel J, Gannon, Melissa R, Meade, Angela M, Sydes, Matthew R, Parmar, Mahesh KB
Published in Clin Trials (2020)

Postoperative radiotherapy for non‐small cell lung cancer

by Burdett, Sarah, Rydzewska, Larysa, Tierney, Jayne, Fisher, David, Parmar, Mahesh KB, Arriagada, Rodrigo, Pignon, Jean Pierre, Le Pechoux, Cecile
Published in Cochrane Database Syst Rev (2016)