Gaining acceptance in next generation PBK modelling approaches for regulatory assessments – An OECD international effort

od Paini, Alicia, Tan, Yu-Mei, Sachana, Magdalini, Worth, Andrew
Wydane w Comput Toxicol (2021)

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – A case study with caffeine

od Bessems, Jos G.M., Paini, Alicia, Gajewska, Monika, Worth, Andrew
Wydane w Toxicology (2017)

Assessment of the predictive capacity of a physiologically based kinetic model using a read-across approach

od Paini, Alicia, Worth, Andrew, Kulkarni, Sunil, Ebbrell, David, Madden, Judith
Wydane w Comput Toxicol (2021)

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

od Paini, Alicia, Sala Benito, Jose Vicente, Bessems, Jos, Worth, Andrew P.
Wydane w Toxicol In Vitro (2017)

Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications

od Paini, Alicia, Leonard, Jeremy A., Kliment, Tomas, Tan, Yu-Mei, Worth, Andrew
Wydane w Regul Toxicol Pharmacol (2017)

Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review

od Desalegn, Anteneh, Bopp, Stephanie, Asturiol, David, Lamon, Lara, Worth, Andrew, Paini, Alicia
Wydane w Comput Toxicol (2019)

Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes

od Worth, Andrew P., Louisse, Jochem, Macko, Peter, Sala Benito, J.V., Paini, Alicia
Wydane w Toxicol In Vitro (2017)

Aggregate Exposure Pathways in Support of Risk Assessment

od Tan, Yu-Mei, Leonard, Jeremy A., Edwards, Stephen, Teeguarden, Justin, Paini, Alicia, Egeghy, Peter
Wydane w Curr Opin Toxicol (2018)

Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

od Clerbaux, Laure-Alix, Coecke, Sandra, Lumen, Annie, Kliment, Tomas, Worth, Andrew P., Paini, Alicia
Wydane w Sci Total Environ (2018)

Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

od Clerbaux, Laure-Alix, Paini, Alicia, Lumen, Annie, Osman-Ponchet, Hanan, Worth, Andrew P., Fardel, Olivier
Wydane w Environ Int (2019)

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

od Terron, Andrea, Bal-Price, Anna, Paini, Alicia, Monnet-Tschudi, Florianne, Bennekou, Susanne Hougaard, Leist, Marcel, Schildknecht, Stefan
Wydane w Arch Toxicol (2017)

The virtual cell based assay: Current status and future perspectives

od Graepel, Rabea, Lamon, Lara, Asturiol, David, Berggren, Elisabet, Joossens, Elisabeth, Paini, Alicia, Prieto, Pilar, Whelan, Maurice, Worth, Andrew
Wydane w Toxicol In Vitro (2017)

Automated workflows for modelling chemical fate, kinetics and toxicity

od Sala Benito, J.V., Paini, Alicia, Richarz, Andrea-Nicole, Meinl, Thorsten, Berthold, Michael R., Cronin, Mark T.D., Worth, Andrew P.
Wydane w Toxicol In Vitro (2017)

Physiologically based kinetic (PBK) modelling and human biomonitoring data for mixture risk assessment

od Pletz, Julia, Blakeman, Samantha, Paini, Alicia, Parissis, Nikolaos, Worth, Andrew, Andersson, Anna-Maria, Frederiksen, Hanne, Sakhi, Amrit K., Thomsen, Cathrine, Bopp, Stephanie K.
Wydane w Environ Int (2020)

Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats

od Punt, Ans, Paini, Alicia, Boersma, Marelle G., Freidig, Andreas P., Delatour, Thierry, Scholz, Gabriele, Schilter, Benoît, van Bladeren, Peter J., Rietjens, Ivonne M. C. M.
Wydane 2009

Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods

od Berggren, Elisabet, White, Andrew, Ouedraogo, Gladys, Paini, Alicia, Richarz, Andrea-Nicole, Bois, Frederic Y., Exner, Thomas, Leite, Sofia, Grunsven, Leo A. van, Worth, Andrew, Mahony, Catherine
Wydane w Comput Toxicol (2017)

Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies

od Pistollato, Francesca, Madia, Federica, Corvi, Raffaella, Munn, Sharon, Grignard, Elise, Paini, Alicia, Worth, Andrew, Bal-Price, Anna, Prieto, Pilar, Casati, Silvia, Berggren, Elisabet, Bopp, Stephanie K, Zuang, Valérie
Wydane w Arch Toxicol (2021)

PBPK model reporting template for chemical risk assessment applications

od Tan, Yu-Mei, Chan, Melissa, Chukwudebe, Amechi, Domoradzki, Jeanne, Fisher, Jeffrey, Hack, C. Eric, Hinderliter, Paul, Hirasawa, Kota, Leonard, Jeremy, Lumen, Annie, Paini, Alicia, Qian, Hua, Ruiz, Patricia, Wambaugh, John, Zhang, Fagen, Embry, Michelle
Wydane w Regul Toxicol Pharmacol (2020)

Representing the Process of Inflammation as Key Events in Adverse Outcome Pathways

od Villeneuve, Daniel L., Landesmann, Brigitte, Allavena, Paola, Ashley, Noah, Bal-Price, Anna, Corsini, Emanuela, Halappanavar, Sabina, Hussell, Tracy, Laskin, Debra, Lawrence, Toby, Nikolic-Paterson, David, Pallardy, Marc, Paini, Alicia, Pieters, Raymond, Roth, Robert, Tschudi-Monnet, Florianne
Wydane w Toxicol Sci (2018)

Putative adverse outcome pathways relevant to neurotoxicity

od Bal-Price, Anna, Crofton, Kevin M., Sachana, Magdalini, Shafer, Timothy J., Behl, Mamta, Forsby, Anna, Hargreaves, Alan, Landesmann, Brigitte, Lein, Pamela J., Louisse, Jochem, Monnet-Tschudi, Florianne, Paini, Alicia, Rolaki, Alexandra, Schrattenholz, André, Suñol, Cristina, van Thriel, Christoph, Whelan, Maurice, Fritsche, Ellen
Wydane w Crit Rev Toxicol (2015)