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From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

Physiologically based kinetic (PBK) models and the virtual cell based assay can be linked to form so called physiologically based dynamic (PBD) models. This study illustrates the development and application of a PBK model for prediction of estragole-induced DNA adduct formation and hepatotoxicity in...

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Bibliografische gegevens
Gepubliceerd in:Toxicol In Vitro
Hoofdauteurs: Paini, Alicia, Sala Benito, Jose Vicente, Bessems, Jos, Worth, Andrew P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Pergamon Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742636/
https://ncbi.nlm.nih.gov/pubmed/28663056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2017.06.015
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