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Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes

In order to replace the use of animals in toxicity testing, there is a need to predict human in vivo toxic doses from concentrations that cause adverse effects in in vitro test systems. The virtual cell based assay (VCBA) has been developed to simulate intracellular concentrations as a function of t...

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Detalhes bibliográficos
Publicado no:Toxicol In Vitro
Main Authors: Worth, Andrew P., Louisse, Jochem, Macko, Peter, Sala Benito, J.V., Paini, Alicia
Formato: Artigo
Idioma:Inglês
Publicado em: Pergamon Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745147/
https://ncbi.nlm.nih.gov/pubmed/28911986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2017.09.009
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