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Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes

In order to replace the use of animals in toxicity testing, there is a need to predict human in vivo toxic doses from concentrations that cause adverse effects in in vitro test systems. The virtual cell based assay (VCBA) has been developed to simulate intracellular concentrations as a function of t...

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Dades bibliogràfiques
Publicat a:Toxicol In Vitro
Autors principals: Worth, Andrew P., Louisse, Jochem, Macko, Peter, Sala Benito, J.V., Paini, Alicia
Format: Artigo
Idioma:Inglês
Publicat: Pergamon Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745147/
https://ncbi.nlm.nih.gov/pubmed/28911986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2017.09.009
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