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Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

Humans are continuously exposed to low levels of thousands of industrial chemicals, most of which are poorly characterised in terms of their potential toxicity. The new paradigm in chemical risk assessment (CRA) aims to rely on animal-free testing, with kinetics being a key determinant of toxicity w...

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Detalhes bibliográficos
Publicado no:Environ Int
Main Authors: Clerbaux, Laure-Alix, Paini, Alicia, Lumen, Annie, Osman-Ponchet, Hanan, Worth, Andrew P., Fardel, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441651/
https://ncbi.nlm.nih.gov/pubmed/30856453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.envint.2019.03.003
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