Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making

The fields of toxicology and chemical risk assessment seek to reduce, and eventually replace, the use of animals for the prediction of toxicity in humans. In this context, physiologically based kinetic (PBK) modelling based on in vitro and in silico kinetic data has the potential to a play significa...

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Publicado en:Comput Toxicol
Main Authors: Paini, A., Leonard, J.A., Joossens, E., Bessems, J.G.M., Desalegn, A., Dorne, J.L., Gosling, J.P., Heringa, M.B., Klaric, M., Kliment, T., Kramer, N.I., Loizou, G., Louisse, J., Lumen, A., Madden, J.C., Patterson, E.A., Proença, S., Punt, A., Setzer, R.W., Suciu, N., Troutman, J., Yoon, M., Worth, A., Tan, Y.M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier B.V 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472623/
https://ncbi.nlm.nih.gov/pubmed/31008414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.comtox.2018.11.002
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