ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion

Por Vigil, Dominico, Kim, Tai Young, Plachco, Ana, Garton, Andrew J., Castaldo, Linda, Pachter, Jonathan A., Dong, Hanqing, Chen, Xin, Tokar, Brianna, Campbell, Sharon L., Der, Channing J.
Publicado em 2012

Synergism of FAK and tyrosine kinase inhibition in Ph(+) B-ALL

Por Churchman, Michelle L., Evans, Kathryn, Richmond, Jennifer, Robbins, Alissa, Jones, Luke, Shapiro, Irina M., Pachter, Jonathan A., Weaver, David T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B., Mullighan, Charles G.
Publicado no JCI Insight (2016)

Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53-miR34a-c-Met Axis

Por Menges, Craig W., Kadariya, Yuwaraj, Altomare, Deborah, Talarchek, Jacqueline, Neumann-Domer, Erin, Wu, Yue, Xiao, Guang-Hui, Shapiro, Irina M., Kolev, Vihren N., Pachter, Jonathan A., Klein-Szanto, Andres J., Testa, Joseph R.
Publicado em 2013

Merlin deficiency predicts for FAK inhibitor sensitivity: A synthetic lethal relationship

Por Shapiro, Irina M., Kolev, Vihren N., Vidal, Christian M., Kadariya, Yuwaraj, Ring, Jennifer E., Wright, Quentin, Weaver, David T., Menges, Craig, Padval, Mahesh, McClatchey, Andrea I., Xu, Qunli, Testa, Joseph R., Pachter, Jonathan A.
Publicado em 2014

Targeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy

Por Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L., Zhu, Yu, Herndon, John M., Meyer, Melissa A., Nywening, Timothy M., Hawkins, William G., Shapiro, Irina M., Weaver, David T., Pachter, Jonathan A., Wang-Gillam, Andrea, DeNardo, David G.
Publicado no Nat Med (2016)

Discovery of Novel Insulin-Like Growth Factor-1 Receptor Inhibitors with Unique Time-Dependent Binding Kinetics

Por Jin, Meizhong, Petronella, Brenda A., Cooke, Andy, Kadalbajoo, Mridula, Siu, Kam W., Kleinberg, Andrew, May, Earl W., Gokhale, Prafulla C., Schulz, Ryan, Kahler, Jennifer, Bittner, Mark A., Foreman, Kenneth, Pachter, Jonathan A., Wild, Robert, Epstein, David, Mulvihill, Mark J.
Publicado em 2013

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Por Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.
Publicado no Cell (2015)

Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR

Por Jin, Meizhong, Gokhale, Prafulla C., Cooke, Andy, Foreman, Kenneth, Buck, Elizabeth, May, Earl W., Feng, Lixin, Bittner, Mark A., Kadalbajoo, Mridula, Landfair, Darla, Siu, Kam W., Stolz, Kathryn M., Werner, Douglas S., Laufer, Radoslaw S., Li, An-Hu, Dong, Hanqing, Steinig, Arno G., Kleinberg, Andrew, Yao, Yan, Pachter, Jonathan A., Wild, Robert, Mulvihill, Mark J.
Publicado em 2010