Merlin deficiency predicts for FAK inhibitor sensitivity: A synthetic lethal relationship

The goal of targeted therapy is to match a selective drug with a genetic lesion that predicts for drug sensitivity. In a diverse panel of cancer cell lines, we found that the cells most sensitive to focal adhesion kinase (FAK) inhibition are deficient in the expression of the NF2 tumor suppressor ge...

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Detalhes bibliográficos
Main Authors: Shapiro, Irina M., Kolev, Vihren N., Vidal, Christian M., Kadariya, Yuwaraj, Ring, Jennifer E., Wright, Quentin, Weaver, David T., Menges, Craig, Padval, Mahesh, McClatchey, Andrea I., Xu, Qunli, Testa, Joseph R., Pachter, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165339/
https://ncbi.nlm.nih.gov/pubmed/24848258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008639
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