Inhibition of FAK kinase activity preferentially targets cancer stem cells

Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and VS-6063 are potent inhibitors of focal adhesion kinase (FAK), a non-receptor t...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kolev, Vihren N., Tam, Winnie F., Wright, Quentin G., McDermott, Sean P., Vidal, Christian M., Shapiro, Irina M., Xu, Qunli, Wicha, Max S., Pachter, Jonathan A., Weaver, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584283/
https://ncbi.nlm.nih.gov/pubmed/28881682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18517
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