Synergism of FAK and tyrosine kinase inhibition in Ph(+) B-ALL

BCR-ABL1(+) B progenitor acute lymphoblastic leukemia (Ph(+) B-ALL) is an aggressive disease that frequently responds poorly to currently available therapies. Alterations in IKZF1, which encodes the lymphoid transcription factor Ikaros, are present in over 80% of Ph(+) ALL and are associated with a...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Churchman, Michelle L., Evans, Kathryn, Richmond, Jennifer, Robbins, Alissa, Jones, Luke, Shapiro, Irina M., Pachter, Jonathan A., Weaver, David T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B., Mullighan, Charles G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844070/
https://ncbi.nlm.nih.gov/pubmed/27123491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86082
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