Acute sensitivity of Ph-like acute lymphoblastic leukemia to the SMAC-mimetic birinapant

Ph-like acute lymphoblastic leukemia (ALL) is a genetically defined high-risk ALL subtype with a generally poor prognosis. In this study, we evaluated the efficacy of birinapant, a small molecule mimetic of the apoptotic regulator SMAC, against a diverse set of ALL subtypes. Birinapant exhibited pot...

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Publicado en:Cancer Res
Autores principales: Richmond, Jennifer, Robbins, Alissa, Evans, Kathryn, Beck, Dominik, Kurmasheva, Raushan T., Billups, Catherine A., Carol, Hernan, Heatley, Sue, Sutton, Rosemary, Marshall, Glenn M., White, Deborah, Pimanda, John, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970887/
https://ncbi.nlm.nih.gov/pubmed/27302164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0523
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