AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of efficacy in adult leukemia clinical trials. Originally designed to target hypoxic cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3). The aim of this study was to test whether AKR1C3 i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Moradi Manesh, Donya, El-Hoss, Jad, Evans, Kathryn, Richmond, Jennifer, Toscan, Cara E., Bracken, Lauryn S., Hedrick, Ashlee, Sutton, Rosemary, Marshall, Glenn M., Wilson, William R., Kurmasheva, Raushan T., Billups, Catherine, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Lock, Richard B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2015
Pynciau:
Lymphoid Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559932/
https://ncbi.nlm.nih.gov/pubmed/26116659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-618900
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