AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia

PR-104, a phosphate ester of the nitrogen mustard prodrug PR-104A, has shown evidence of efficacy in adult leukemia clinical trials. Originally designed to target hypoxic cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3). The aim of this study was to test whether AKR1C3 i...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Moradi Manesh, Donya, El-Hoss, Jad, Evans, Kathryn, Richmond, Jennifer, Toscan, Cara E., Bracken, Lauryn S., Hedrick, Ashlee, Sutton, Rosemary, Marshall, Glenn M., Wilson, William R., Kurmasheva, Raushan T., Billups, Catherine, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559932/
https://ncbi.nlm.nih.gov/pubmed/26116659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-618900
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