Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

The clinical success of the BCL-2-selective BH3-mimetic venetoclax in patients with poor prognosis chronic lymphocytic leukemia (CLL) highlights the potential of targeting the BCL-2-regulated apoptotic pathway in previously untreatable lymphoid malignancies. By selectively inhibiting BCL-2, venetocl...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Khaw, Seong Lin, Suryani, Santi, Evans, Kathryn, Richmond, Jennifer, Robbins, Alissa, Kurmasheva, Raushan T., Billups, Catherine A., Erickson, Stephen W., Guo, Yuelong, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Roberts, Andrew W., Huang, David C. S., Lock, Richard B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2016
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016707/
https://ncbi.nlm.nih.gov/pubmed/27343252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707414
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