Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia

The clinical success of the BCL-2-selective BH3-mimetic venetoclax in patients with poor prognosis chronic lymphocytic leukemia (CLL) highlights the potential of targeting the BCL-2-regulated apoptotic pathway in previously untreatable lymphoid malignancies. By selectively inhibiting BCL-2, venetocl...

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Veröffentlicht in:Blood
Hauptverfasser: Khaw, Seong Lin, Suryani, Santi, Evans, Kathryn, Richmond, Jennifer, Robbins, Alissa, Kurmasheva, Raushan T., Billups, Catherine A., Erickson, Stephen W., Guo, Yuelong, Houghton, Peter J., Smith, Malcolm A., Carol, Hernan, Roberts, Andrew W., Huang, David C. S., Lock, Richard B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016707/
https://ncbi.nlm.nih.gov/pubmed/27343252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-03-707414
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