The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

PURPOSE: Inhibitor of apoptosis proteins (IAPs) promote cancer cell survival and confer resistance to therapy. We report on the ability of second mitochondria-derived activator of caspases (SMAC) mimetic, birinapant, which acts as antagonist to cIAP1 and cIAP2, to restore the sensitivity to apoptoti...

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Autori principali: Krepler, Clemens, Chunduru, Srinivas K., Halloran, Molly B., He, Xu, Xiao, Min, Vultur, Adina, Villanueva, Jessie, Mitsuuchi, Yasuhiro, Neiman, Eric M., Benetatos, Christopher, Nathanson, Katherine L., Amaravadi, Ravi K., Pehamberger, Hubert, McKinlay, Mark, Herlyn, Meenhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618495/
https://ncbi.nlm.nih.gov/pubmed/23403634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2518
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