The novel SMAC mimetic birinapant exhibits potent activity against human melanoma cells

PURPOSE: Inhibitor of apoptosis proteins (IAPs) promote cancer cell survival and confer resistance to therapy. We report on the ability of second mitochondria-derived activator of caspases (SMAC) mimetic, birinapant, which acts as antagonist to cIAP1 and cIAP2, to restore the sensitivity to apoptoti...

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Bibliografski detalji
Glavni autori: Krepler, Clemens, Chunduru, Srinivas K., Halloran, Molly B., He, Xu, Xiao, Min, Vultur, Adina, Villanueva, Jessie, Mitsuuchi, Yasuhiro, Neiman, Eric M., Benetatos, Christopher, Nathanson, Katherine L., Amaravadi, Ravi K., Pehamberger, Hubert, McKinlay, Mark, Herlyn, Meenhard
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618495/
https://ncbi.nlm.nih.gov/pubmed/23403634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2518
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