Targeting triple-negative breast cancers with the Smac-mimetic birinapant

Smac mimetics target inhibitor of apoptosis (IAP) proteins, thereby suppressing their function to facilitate tumor cell death. Here we have evaluated the efficacy of the preclinical Smac-mimetic compound A and the clinical lead birinapant on breast cancer cells. Both exhibited potent in vitro activi...

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Vydáno v:Cell Death Differ
Hlavní autoři: Lalaoui, Najoua, Merino, Delphine, Giner, Goknur, Vaillant, François, Chau, Diep, Liu, Lin, Kratina, Tobias, Pal, Bhupinder, Whittle, James R., Etemadi, Nima, Berthelet, Jean, Gräsel, Julius, Hall, Cathrine, Ritchie, Matthew E., Ernst, Matthias, Smyth, Gordon K., Vaux, David L., Visvader, Jane E., Lindeman, Geoffrey J., Silke, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492458/
https://ncbi.nlm.nih.gov/pubmed/32341449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0541-0
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