Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53-miR34a-c-Met Axis

Malignant mesothelioma (MM) is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbestos-induced MM compared to asbestos-exposed N...

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Autors principals: Menges, Craig W., Kadariya, Yuwaraj, Altomare, Deborah, Talarchek, Jacqueline, Neumann-Domer, Erin, Wu, Yue, Xiao, Guang-Hui, Shapiro, Irina M., Kolev, Vihren N., Pachter, Jonathan A., Klein-Szanto, Andres J., Testa, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945416/
https://ncbi.nlm.nih.gov/pubmed/24371224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2062
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