Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are CDKN2A, which encodes components of the p53 (p14ARF) and RB (p16INK4A) pathways, BAP1, and NF2. Furthermore, the p53 g...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Sementino, Eleonora, Menges, Craig W., Kadariya, Yuwaraj, Peri, Suraj, Xu, Jinfei, Liu, Zemin, Wilkes, Richard G., Cai, Kathy Q., Rauscher, Frank J., Klein-Szanto, Andres J., Testa, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168364/
https://ncbi.nlm.nih.gov/pubmed/29904909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26830
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