Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

PURPOSE: Receptor-interacting protein kinase RIPK3 phosphorylates effector molecule MLKL to trigger necroptosis. Although RIPK3 loss is seen in several human cancers, its role in malignant mesothelioma (MM) is unknown. This study aimed to determine if RIPK3 functions as a potential tumor suppressor...

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Publicado en:Clin Cancer Res
Autores principales: Tan, Yinfei, Sementino, Eleonora, Cheung, Mitchell, Peri, Suraj, Menges, Craig W., Kukuyan, Anna-Mariya, Zhang, Ting, Khazak, Vladimir, Fox, Lauren A., Ross, Eric, Ramanathan, Suresh, Jhanwar, Suresh C., Flores, Raja M., Balachandran, Siddharth, Testa, Joseph R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7887036/
https://ncbi.nlm.nih.gov/pubmed/33203643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3683
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