Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Malignant mesotheliomas are highly aggressive tumors usually caused by exposure to asbestos. Germline inactivating mutations of BAP1 predispose to mesothelioma and certain other cancers. However, why mesothelioma is the predominate malignancy in some BAP1 families and not others, and whether exposur...

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Detalhes bibliográficos
Main Authors: Xu, Jinfei, Kadariya, Yuwaraj, Cheung, Mitchell, Pei, Jianming, Talarchek, Jacqueline, Sementino, Eleonora, Tan, Yinfei, Menges, Craig W., Cai, Kathy Q., Litwin, Samuel, Peng, Hongzhuang, Karar, Jayashree, Rauscher, Frank J., Testa, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4165574/
https://ncbi.nlm.nih.gov/pubmed/24928783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1328
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