Germline BAP1 mutations predispose to malignant mesothelioma

Because only a small fraction of asbestos-exposed individuals develop malignant mesothelioma(1), and because mesothelioma clustering is observed in some families(1), we searched for genetic predisposing factors. We discovered germline mutations in BAP1 (BRCA1-associated protein 1) in two families wi...

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Autori principali: Testa, Joseph R., Cheung, Mitchell, Pei, Jianming, Below, Jennifer E., Tan, Yinfei, Sementino, Eleonora, Cox, Nancy J., Dogan, A. Umran, Pass, Harvey I., Trusa, Sandra, Hesdorffer, Mary, Nasu, Masaki, Powers, Amy, Rivera, Zeyana, Comertpay, Sabahattin, Tanji, Mika, Gaudino, Giovanni, Yang, Haining, Carbone, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184199/
https://ncbi.nlm.nih.gov/pubmed/21874000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.912
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