High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma

BACKGROUND: BAP1 is a nuclear deubiquitinase that regulates gene expression, transcription, DNA repair, and more. Several findings underscore the apparent “driver” role of BAP1 in malignant mesothelioma (MM). However the reported frequency of somatic BAP1 mutations in MM varies considerably, a discr...

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Detalhes bibliográficos
Publicado no:J Thorac Oncol
Main Authors: Nasu, Masaki, Emi, Mitsuru, Pastorino, Sandra, Tanji, Mika, Powers, Amy, Luk, Hugh, Baumann, Francine, Zhang, Yu-an, Gazdar, Adi, Kanodia, Shreya, Tiirikainen, Maarit, Flores, Erin, Gaudino, Giovanni, Becich, Michael J., Pass, Harvey I., Yang, Haining, Carbone, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408084/
https://ncbi.nlm.nih.gov/pubmed/25658628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0000000000000471
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