Bap1 is a bona fide tumor suppressor: genetic evidence from mouse models carrying heterozygous germline Bap1 mutations

Individuals harboring inherited heterozygous germline mutations in BAP1 are predisposed to a range of benign and malignant tumor types, including malignant mesothelioma, melanoma, and kidney carcinoma. However, evidence to support a tumor suppressive role for BAP1 in cancer remains contradictory. To...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Kadariya, Yuwaraj, Cheung, Mitchell, Xu, Jinfei, Pei, Jianming, Sementino, Eleonora, Menges, Craig W., Cai, Kathy Q., Rauscher, Frank J., Klein-Szanto, Andres J., Testa, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873414/
https://ncbi.nlm.nih.gov/pubmed/26896281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-3371
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