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Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

Malignant mesothelioma (MM) is a therapy-resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are CDKN2A, which encodes components of the p53 (p14ARF) and RB (p16INK4A) pathways, BAP1, and NF2. Furthermore, the p53 g...

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Bibliografische gegevens
Gepubliceerd in:J Cell Physiol
Hoofdauteurs: Sementino, Eleonora, Menges, Craig W., Kadariya, Yuwaraj, Peri, Suraj, Xu, Jinfei, Liu, Zemin, Wilkes, Richard G., Cai, Kathy Q., Rauscher, Frank J., Klein-Szanto, Andres J., Testa, Joseph R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168364/
https://ncbi.nlm.nih.gov/pubmed/29904909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.26830
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