Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR

Por Jin, Meizhong, Gokhale, Prafulla C., Cooke, Andy, Foreman, Kenneth, Buck, Elizabeth, May, Earl W., Feng, Lixin, Bittner, Mark A., Kadalbajoo, Mridula, Landfair, Darla, Siu, Kam W., Stolz, Kathryn M., Werner, Douglas S., Laufer, Radoslaw S., Li, An-Hu, Dong, Hanqing, Steinig, Arno G., Kleinberg, Andrew, Yao, Yan, Pachter, Jonathan A., Wild, Robert, Mulvihill, Mark J.
Publicado em 2010

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

Por Liu, Yong, Laufer, Radoslaw, Patel, Narendra Kumar, Ng, Grace, Sampson, Peter B., Li, Sze-Wan, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Plotnikova, Olga, Awrey, Donald E., Qiu, Wei, Chirgadze, Nickolay Y., Mason, Jacqueline M., Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Fletcher, Graham C., Mak, Tak W., Bray, Mark R., Pauls, Henry W.
Publicado no ACS Med Chem Lett (2016)