Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis

di Ozcan, Lale, Tabas, Ira
Pubblicazione 2010

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

di Ozcan, Lale, Tabas, Ira
Pubblicazione 2012

CaMKII in Cardiometabolic Disease

di Ozcan, Lale, Tabas, Ira
Pubblicazione 2014

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

di Ozcan, Lale, Tabas, Ira
Pubblicato in Diabetes (2018)

Common Therapeutic Targets in Cardiometabolic Disease

di Fredman, Gabrielle, Ozcan, Lale, Tabas, Ira
Pubblicazione 2014

Targeting Soluble DPP-4 for Insulin Resistance: Origin Matters

di Ozcan, Lale, Ghorpade, Devram S, Tabas, Ira
Pubblicato in J Clin Endocrinol Metab (2020)

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

di Li, Gang, Scull, Christopher, Ozcan, Lale, Tabas, Ira
Pubblicazione 2010

PCSK9 and Lipid Metabolism

di Spolitu, Stefano, Dai, Wen, Zadroga, John A., Ozcan, Lale
Pubblicato in Curr Opin Lipidol (2019)

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

di Subramanian, Manikandan, Ozcan, Lale, Ghorpade, Devram Sampat, Ferrante, Anthony W., Tabas, Ira
Pubblicato in PLoS One (2015)

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B(4) synthesis by inhibiting a calcium-activated kinase pathway

di Fredman, Gabrielle, Ozcan, Lale, Spolitu, Stefano, Hellmann, Jason, Spite, Matthew, Backs, Johannes, Tabas, Ira
Pubblicazione 2014

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

di Ozcan, Umut, Ozcan, Lale, Yilmaz, Erkan, Düvel, Katrin, Sahin, Mustafa, Manning, Brendan D., Hotamisligil, Gökhan S.
Pubblicazione 2008

Hepatic Glucagon Signaling Regulates PCSK9 and LDL-Cholesterol

di Spolitu, Stefano, Okamoto, Haruka, Dai, Wen, Zadroga, John A., Wittchen, Erika S., Gromada, Jesper, Ozcan, Lale
Pubblicato in Circ Res (2019)

Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

di Ozcan, Lale, de Souza, Jane Cristina, Harari, Alp Avi, Backs, Johannes, Olson, Eric N., Tabas, Ira
Pubblicazione 2013

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis

di Ozcan, Lale, Kasikara, Canan, Yurdagul, Arif, Kuriakose, George, Hubbard, Brian, Serrano-Wu, Michael H., Tabas, Ira
Pubblicato in PLoS One (2021)

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

di Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O., Görgün, Cem Z., Hotamisligil, Gökhan S.
Pubblicato in Science (2006)

Degradation of PHLPP2 by KCTD17, via a Glucagon-dependent Pathway, Promotes Hepatic Steatosis

di Kim, KyeongJin, Ryu, Dongryeol, Dongiovanni, Paola, Ozcan, Lale, Nayak, Shruti, Ueberheide, Beatrix, Valenti, Luca, Auwerx, Johan, Pajvani, Utpal B.
Pubblicato in Gastroenterology (2017)

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

di Ghorpade, Devram S., Ozcan, Lale, Zheng, Ze, Nicoloro, Sarah M., Shen, Yuefei, Chen, Emily, Blüher, Matthias, Czech, Michael P., Tabas, Ira
Pubblicato in Nature (2018)

Hepatocyte DACH1 is Increased in Obesity Via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

di Ozcan, Lale, Ghorpade, Devram S., Zheng, Ze, de Souza, Jane Cristina, Chen, Ke, Bessler, Marc, Bagloo, Melissa, Schrope, Beth, Pestell, Richard, Tabas, Ira
Pubblicato in Cell Rep (2016)

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

di Ozcan, Lale, Xu, Xiaoming, Deng, Shi-Xian, Ghorpade, Devram S., Thomas, Tiffany, Cremers, Serge, Hubbard, Brian, Serrano-Wu, Michael H., Gaestel, Matthias, Landry, Donald W., Tabas, Ira
Pubblicato in Diabetes (2015)

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1

di Zheng, Ze, Nayak, Lalitha, Wang, Wei, Yurdagul, Arif, Wang, Xiaobo, Cai, Bishuang, Lapping, Stephanie, Ozcan, Lale, Ramakrishnan, Rajasekhar, Pestell, Richard G., Jain, Mukesh K., Tabas, Ira
Pubblicato in Blood (2019)