Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B(4) synthesis by inhibiting a calcium-activated kinase pathway

Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of pr...

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Bibliographic Details
Main Authors: Fredman, Gabrielle, Ozcan, Lale, Spolitu, Stefano, Hellmann, Jason, Spite, Matthew, Backs, Johannes, Tabas, Ira
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210018/
https://ncbi.nlm.nih.gov/pubmed/25246560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410851111
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