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Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B(4) synthesis by inhibiting a calcium-activated kinase pathway
Imbalances between proinflammatory and proresolving mediators can lead to chronic inflammatory diseases. The balance of arachidonic acid-derived mediators in leukocytes is thought to be achieved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthesis of pr...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210018/ https://ncbi.nlm.nih.gov/pubmed/25246560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410851111 |
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