Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin Signaling

A hallmark of obesity is selective suppression of hepatic insulin signaling (“insulin resistance”), but critical gaps remain in our understanding of the molecular mechanisms. We now report a major role for hepatic CaMKII, a calcium-responsive kinase that is activated in obesity. Genetic targeting of...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Ozcan, Lale, de Souza, Jane Cristina, Harari, Alp Avi, Backs, Johannes, Olson, Eric N., Tabas, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863383/
https://ncbi.nlm.nih.gov/pubmed/24268736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.10.011
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky