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Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a variety of cellular processes including growth, proliferation and metabolism. Loss of the tuberous sclerosis complex genes (TSC1 or TSC2) leads to constitutive activation of mTOR an...

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Detalhes bibliográficos
Main Authors: Ozcan, Umut, Ozcan, Lale, Yilmaz, Erkan, Düvel, Katrin, Sahin, Mustafa, Manning, Brendan D., Hotamisligil, Gökhan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361721/
https://ncbi.nlm.nih.gov/pubmed/18342602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.12.023
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