Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

Obesity-induced metabolic disease involves functional integration among several organs via circulating factors, but little is known about crosstalk between liver and visceral adipose tissue (VAT)(1). In obesity, VAT becomes populated with inflammatory adipose tissue macrophages (ATMs)(2,3). In obese...

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Gepubliceerd in:Nature
Hoofdauteurs: Ghorpade, Devram S., Ozcan, Lale, Zheng, Ze, Nicoloro, Sarah M., Shen, Yuefei, Chen, Emily, Blüher, Matthias, Czech, Michael P., Tabas, Ira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021131/
https://ncbi.nlm.nih.gov/pubmed/29562231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature26138
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