Genetic Variants in mRNA Untranslated Regions

Por Steri, Maristella, Idda, M. Laura, Whalen, Michael B., Orrù, Valeria
Publicado no Wiley Interdiscip Rev RNA (2018)

Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia

Por Delitala, Alessandro P, Terracciano, Antonio, Fiorillo, Edoardo, Orrù, Valeria, Schlessinger, David, Cucca, Francesco
Publicado no J Affect Disord (2015)

Regulation of Lymphoid Tyrosine Phosphatase Activity: Inhibition of the Catalytic Domain by the Proximal Interdomain

Por Liu, Yingge, Stanford, Stephanie M., Jog, Sonali P., Fiorillo, Edoardo, Orrú, Valeria, Comai, Lucio, Bottini, Nunzio
Publicado em 2009

Carotid Beta Stiffness Association with Thyroid Function

Por Delitala, Alessandro P., Scuteri, Angelo, Fiorillo, Edoardo, Orrù, Valeria, Lakatta, Edward G., Schlessinger, David, Cucca, Francesco
Publicado no J Clin Med (2021)

Crystal Structure Of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights Into Redox Regulation,

Por Tsai, Sophia J., Sen, Udayaditya, Zhao, Lei, Greenleaf, William B., Dasgupta, Jhimli, Fiorillo, Edoardo, Orrú, Valeria, Bottini, Nunzio, Chen, Xiaojiang S.
Publicado em 2009

Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

Por Lodde, Valeria, Floris, Matteo, Beerman, Isabel, Munk, Rachel, Guha, Rajan, Steri, Maristella, Orrù, Valeria, Abdelmohsen, Kotb, Crompton, Peter D., Gorospe, Myriam, Idda, Maria Laura, Cucca, Francesco
Publicado no Front Immunol (2020)

CD8(+)HLADR(+) Regulatory T Cells Change With Aging: They Increase in Number, but Lose Checkpoint Inhibitory Molecules and Suppressive Function

Por Lukas Yani, Stella, Keller, Michael, Melzer, Franz Leonard, Weinberger, Birgit, Pangrazzi, Luca, Sopper, Sieghart, Trieb, Klemens, Lobina, Monia, Orrù, Valeria, Fiorillo, Edoardo, Cucca, Francesco, Grubeck-Loebenstein, Beatrix
Publicado no Front Immunol (2018)

Cooperative translational control of polymorphic BAFF by NF90 and miR-15a

Por Idda, M Laura, Lodde, Valeria, McClusky, Waverly G, Martindale, Jennifer L, Yang, Xiaoling, Munk, Rachel, Steri, Maristella, Orrù, Valeria, Mulas, Antonella, Cucca, Francesco, Abdelmohsen, Kotb, Gorospe, Myriam
Publicado no Nucleic Acids Res (2018)

Autoimmunity-Associated LYP-W620 Does Not Impair Thymic Negative Selection of Autoreactive T Cells

Por Wu, Dennis J., Zhou, Wenbo, Enouz, Sarah, Orrú, Valeria, Stanford, Stephanie M., Maine, Christian J., Rapini, Novella, Sawatzke, Kristy, Engel, Isaac, Fiorillo, Edoardo, Sherman, Linda A., Kronenberg, Mitch, Zehn, Dietmar, Peterson, Erik, Bottini, Nunzio
Publicado em 2014

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

Por Fiorillo, Edoardo, Orrú, Valeria, Stanford, Stephanie M., Liu, Yingge, Salek, Mogjiborahman, Rapini, Novella, Schenone, Aaron D., Saccucci, Patrizia, Delogu, Lucia G., Angelini, Federica, Manca Bitti, Maria Luisa, Schmedt, Christian, Chan, Andrew C., Acuto, Oreste, Bottini, Nunzio
Publicado em 2010

Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp(620) Risk Allele Drive the Expansion of FOXP3(+) Regulatory T Cells and PD-1 Expression

Por Ferreira, Ricardo C., Castro Dopico, Xaquin, Oliveira, João J., Rainbow, Daniel B., Yang, Jennie H., Trzupek, Dominik, Todd, Sarah A., McNeill, Mhairi, Steri, Maristella, Orrù, Valeria, Fiorillo, Edoardo, Crouch, Daniel J. M., Pekalski, Marcin L., Cucca, Francesco, Tree, Tim I., Vyse, Tim J., Wicker, Linda S., Todd, John A.
Publicado no Front Immunol (2019)

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

Por Orrú, Valeria, Tsai, Sophia J., Rueda, Blanca, Fiorillo, Edoardo, Stanford, Stephanie M., Dasgupta, Jhimli, Hartiala, Jaana, Zhao, Lei, Ortego-Centeno, Norberto, D’Alfonso, Sandra, Arnett, Frank C., Wu, Hui, Gonzalez-Gay, Miguel A., Tsao, Betty P., Pons-Estel, Bernardo, Alarcon-Riquelme, Marta E., He, Yantao, Zhang, Zhong-Yin, Allayee, Hooman, Chen, Xiaojiang S., Martin, Javier, Bottini, Nunzio
Publicado em 2009

CXCR3 Identifies Human Naive CD8(+) T Cells with Enhanced Effector Differentiation Potential

Por De Simone, Gabriele, Mazza, Emilia M. C., Cassotta, Antonino, Davydov, Alexey N., Kuka, Mirela, Zanon, Veronica, De Paoli, Federica, Scamardella, Eloise, Metsger, Maria, Roberto, Alessandra, Pilipow, Karolina, Colombo, Federico S., Tenedini, Elena, Tagliafico, Enrico, Gattinoni, Luca, Mavilio, Domenico, Peano, Clelia, Price, David A., Singh, Satya P., Farber, Joshua M., Serra, Valentina, Cucca, Francesco, Ferrari, Francesco, Orrù, Valeria, Fiorillo, Edoardo, Iannacone, Matteo, Chudakov, Dmitriy M., Sallusto, Federica, Lugli, Enrico
Publicado no J Immunol (2019)

Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia

Por Pitzalis, Maristella, Zavattari, Patrizia, Murru, Raffaele, Deidda, Elisabetta, Zoledziewska, Magdalena, Murru, Daniela, Moi, Loredana, Motzo, Costantino, Orrù, Valeria, Costa, Gianna, Solla, Elisabetta, Fadda, Elisabetta, Schirru, Lucia, Melis, Maria Cristina, Lai, Marina, Mancosu, Cristina, Tranquilli, Stefania, Cuccu, Stefania, Rolesu, Marcella, Secci, Maria Antonietta, Corongiu, Daniela, Contu, Daniela, Lampis, Rosanna, Nucaro, Annalisa, Pala, Gavino, Pacifico, Adolfo, Maioli, Mario, Frongia, Paola, Chessa, Margherita, Ricciardi, Rossella, Lostia, Stanislao, Marinaro, Anna Maria, Milia, Anna Franca, Landis, Novella, Zedda, Maria Antonietta, Whalen, Michael B, Santoni, Federico, Marrosu, Maria Giovanna, Devoto, Marcella, Cucca, Francesco
Publicado em 2008

Autoimmunity Is a Significant Feature of Idiopathic Pulmonary Arterial Hypertension

Por Jones, Rowena J., De Bie, Eckart M. D. D., Groves, Emily, Zalewska, Kasia I., Swietlik, Emilia M., Treacy, Carmen M., Martin, Jennifer M., Polwarth, Gary, Li, Wei, Guo, Jingxu, Baxendale, Helen E., Coleman, Stephen, Savinykh, Natalia, Coghlan, J. Gerry, Corris, Paul A., Howard, Luke S., Johnson, Martin K., Church, Colin, Kiely, David G., Lawrie, Allan, Lordan, James L., Mackenzie Ross, Robert V., Pepke Zaba, Joanna, Wilkins, Martin R., Wort, S. John, Fiorillo, Edoardo, Orrù, Valeria, Cucca, Francesco, Rhodes, Christopher J., Gräf, Stefan, Morrell, Nicholas W., McKinney, Eoin F., Wallace, Chris, Toshner, Mark
Publicado no Am J Respir Crit Care Med (2022)

PRF1 mutation alters immune system activation, inflammation and risk of autoimmunity

Por Sidore, Carlo, Orrù, Valeria, Cocco, Eleonora, Steri, Maristella, Inshaw, Jamie RJ, Pitzalis, Maristella, Mulas, Antonella, McGurnaghan, Stuart, Frau, Jessica, Porcu, Eleonora, Busonero, Fabio, Dei, Mariano, Lai, Sandra, Sole, Gabriella, Virdis, Francesca, Serra, Valentina, Poddie, Fausto, Delitala, Alessandro, Marongiu, Michele, Deidda, Francesca, Pala, Mauro, Floris, Matteo, Masala, Marco, Onengut-Gumuscu, Suna, Robertson, Catherine C, Leoni, Lidia, Frongia, Annapaola, Ricciardi, Maria Rossella, Chessa, Margherita, Olla, Nazario, Lovicu, Mario, Loizedda, Annalisa, Maschio, Andrea, Mereu, Luisa, Ferrigno, Paola, Curreli, Nicolo, Balaci, Lenuta, Loi, Francesco, Ferreli, Liana AP, Pilia, Maria Grazia, Pani, Antonello, Marrosu, Maria Giovanna, Abecasis, Goncalo R, Rich, Stephen S, Colhoun, Helen, Todd, John A, Schlessinger, David, Fiorillo, Edoardo, Cucca, Francesco, Zoledziewska, Magdalena
Publicado no Mult Scler (2020)

Genetic Variants Regulating Immune Cell Levels in Health and Disease

Por Orrù, Valeria, Steri, Maristella, Sole, Gabriella, Sidore, Carlo, Virdis, Francesca, Dei, Mariano, Lai, Sandra, Zoledziewska, Magdalena, Busonero, Fabio, Mulas, Antonella, Floris, Matteo, Mentzen, Wieslawa I., Urru, Silvana A.M., Olla, Stefania, Marongiu, Michele, Piras, Maria G., Lobina, Monia, Maschio, Andrea, Pitzalis, Maristella, Urru, Maria F., Marcelli, Marco, Cusano, Roberto, Deidda, Francesca, Serra, Valentina, Oppo, Manuela, Pilu, Rosella, Reinier, Frederic, Berutti, Riccardo, Pireddu, Luca, Zara, Ilenia, Porcu, Eleonora, Kwong, Alan, Brennan, Christine, Tarrier, Brendan, Lyons, Robert, Kang, Hyun M., Uzzau, Sergio, Atzeni, Rossano, Valentini, Maria, Firinu, Davide, Leoni, Lidia, Rotta, Gianluca, Naitza, Silvia, Angius, Andrea, Congia, Mauro, Whalen, Michael B., Jones, Chris M., Schlessinger, David, Abecasis, Gonçalo R., Fiorillo, Edoardo, Sanna, Serena, Cucca, Francesco
Publicado no Cell (2013)

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Por Liu, Mengzhen, Jiang, Yu, Wedow, Robbee, Li, Yue, Brazel, David M., Chen, Fang, Datta, Gargi, Davila-Velderrain, Jose, McGuire, Daniel, Tian, Chao, Zhan, Xiaowei, Choquet, Hélène, Docherty, Anna R., Faul, Jessica D., Foerster, Johanna R., Fritsche, Lars G., Gabrielsen, Maiken Elvestad, Gordon, Scott D., Haessler, Jeffrey, Hottenga, Jouke-Jan, Huang, Hongyan, Jang, Seon-Kyeong, Jansen, Philip R., Ling, Yueh, Mägi, Reedik, Matoba, Nana, McMahon, George, Mulas, Antonella, Orrù, Valeria, Palviainen, Teemu, Pandit, Anita, Reginsson, Gunnar W., Skogholt, Anne Heidi, Smith, Jennifer A., Taylor, Amy E., Turman, Constance, Willemsen, Gonneke, Young, Hannah, Young, Kendra A., Zajac, Gregory J. M., Zhao, Wei, Zhou, Wei, Bjornsdottir, Gyda, Boardman, Jason D., Boehnke, Michael, Boomsma, Dorret I., Chen, Chu, Cucca, Francesco, Davies, Gareth E., Eaton, Charles B., Ehringer, Marissa A., Esko, Tõnu, Fiorillo, Edoardo, Gillespie, Nathan A., Gudbjartsson, Daniel F., Haller, Toomas, Harris, Kathleen Mullan, Heath, Andrew C., Hewitt, John K., Hickie, Ian B., Hokanson, John E., Hopfer, Christian J., Hunter, David J., Iacono, William G., Johnson, Eric O., Kamatani, Yoichiro, Kardia, Sharon L. R., Keller, Matthew C., Kellis, Manolis, Kooperberg, Charles, Kraft, Peter, Krauter, Kenneth S., Laakso, Markku, Lind, Penelope A., Loukola, Anu, Lutz, Sharon M., Madden, Pamela A. F., Martin, Nicholas G., McGue, Matt, McQueen, Matthew B., Medland, Sarah E., Metspalu, Andres, Mohlke, Karen L., Nielsen, Jonas B., Okada, Yukinori, Peters, Ulrike, Polderman, Tinca J. C., Posthuma, Danielle, Reiner, Alexander P., Rice, John P., Rimm, Eric, Rose, Richard J., Runarsdottir, Valgerdur, Stallings, Michael C., Stančáková, Alena, Stefansson, Hreinn, Thai, Khanh K., Tindle, Hilary A., Tyrfingsson, Thorarinn, Wall, Tamara L., Weir, David R., Weisner, Constance, Whitfield, John B., Winsvold, Bendik Slagsvold, Yin, Jie, Zuccolo, Luisa, Bierut, Laura J., Hveem, Kristian, Lee, James J., Munafo, Marcus R., Saccone, Nancy L., Willer, Cristen J., Cornelis, Marilyn C., David, Sean P., Hinds, David, Jorgenson, Eric, Kaprio, Jaakko, Stitzel, Jerry A., Stefansson, Kari, Thorgeirsson, Thorgeir E., Abecasis, Goncalo, Liu, Dajiang J., Vrieze, Scott
Publicado no Nat Genet (2019)