Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population signatures revealed that BAFF-var was evolutionar...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lodde, Valeria, Floris, Matteo, Beerman, Isabel, Munk, Rachel, Guha, Rajan, Steri, Maristella, Orrù, Valeria, Abdelmohsen, Kotb, Crompton, Peter D., Gorospe, Myriam, Idda, Maria Laura, Cucca, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573158/
https://ncbi.nlm.nih.gov/pubmed/33123155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.575103
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