N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation

Por Moffett, John R., Arun, Peethambaran, Ariyannur, Prasanth S., Namboodiri, Aryan M. A.
Publicado em 2013

The end of the road for the tryptophan depletion concept in pregnancy and infection

Por Badawy, Abdulla A.-B., Namboodiri, Aryan M.A., Moffett, John R.
Publicado no Clin Sci (Lond) (2016)

Effects of N-Acetylaspartylglutamate (NAAG) Peptidase Inhibition on Release of Glutamate and Dopamine in Prefrontal Cortex and Nucleus Accumbens in Phencyclidine Model of Schizophr...

Por Zuo, Daiying, Bzdega, Tomasz, Olszewski, Rafal T., Moffett, John R., Neale, Joseph H.
Publicado em 2012

N-Acetylaspartate in the CNS: From Neurodiagnostics to Neurobiology

Por Moffett, John R., Ross, Brian, Arun, Peethambaran, Madhavarao, Chikkathur N., Namboodiri, M. A. A.
Publicado em 2007

Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS

Por Appu, Abhilash P, Arun, Peethambaran, Krishnan, Jishnu K. S., Moffett, John R., Namboodiri, Aryan M. A.
Publicado no J Neurosci Methods (2015)

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

Por Yamada Toshihiko, Zuo Daiying, Yamamoto Tatsuo, Olszewski Rafal T, Bzdega Tomasz, Moffett John R, Neale Joseph H
Publicado em 2012-09-01

Extensive Aspartoacylase Expression in the Rat Central Nervous System

Por Moffett, John R., Arun, Peethambaran, Ariyannur, Prasanth S., Garbern, James, Jacobowitz, David M., Namboodiri, Aryan M.A.
Publicado em 2011

NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

Por Yamada, Toshihiko, Zuo, Daiying, Yamamoto, Tatsuo, Olszewski, Rafal T, Bzdega, Tomasz, Moffett, John R, Neale, Joseph H
Publicado em 2012

A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA

Por Nonaka, Takahiro, Yamada, Toshihiko, Ishimura, Tatsuhiro, Zuo, Daiying, Moffett, John R, Neale, Joseph H, Yamamoto, Tatsuo
Publicado no Mol Pain (2017)

N-Acetylaspartate (NAA) and N-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells

Por Long, Patrick M., Moffett, John R., Namboodiri, Aryan M. A., Viapiano, Mariano S., Lawler, Sean E., Jaworski, Diane M.
Publicado em 2013

N-Acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.

Por Long, Patrick M., Moffett, John R., Namboodiri, Aryan M. A., Viapiano, Mariano S., Lawler, Sean E., Jaworski, Diane M.
Publicado em 2013

Metabolic Acetate Therapy for the Treatment of Traumatic Brain Injury

Por Arun, Peethambaran, Ariyannur, Prasanth S., Moffett, John R., Xing, Guoqiang, Hamilton, Kristen, Grunberg, Neil E., Ives, John A., Namboodiri, Aryan M.A.
Publicado em 2010

Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

Por Appu, Abhilash P., Moffett, John R., Arun, Peethambaran, Moran, Sean, Nambiar, Vikram, Krishnan, Jishnu K. S., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Publicado no Front Mol Neurosci (2017)

Effect of Administration Method, Animal Weight and Age on the Intranasal Delivery of Drugs to the Brain

Por Krishnan, Jishnu K.S., Arun, Peethambaran, Chembukave, Bhadra, Appu, Abhilash P., Vijayakumar, Nivetha, Moffett, John R., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Publicado no J Neurosci Methods (2017)

Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

Por Long, Patrick M., Tighe, Scott W., Driscoll, Heather E., Moffett, John R., Namboodiri, Aryan M. A., Viapiano, Mariano S., Lawler, Sean E., Jaworski, Diane M.
Publicado em 2013

Nuclear-cytoplasmic localization of acetyl coenzyme A synthetase-1 in the rat brain

Por Ariyannur, Prasanth S., Moffett, John R., Madhavarao, Chikkathur N, Arun, Peethambaran, Vishnu, Nisha, Jacobowitz, David M., Hallows, William C., Denu, John M., Namboodiri, Aryan M.A.
Publicado em 2010

Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease

Por Madhavarao, Chikkathur N., Arun, Peethambaran, Moffett, John R., Szucs, Sylvia, Surendran, Sankar, Matalon, Reuben, Garbern, James, Hristova, Diana, Johnson, Anne, Jiang, Wei, Namboodiri, M. A. Aryan
Publicado em 2005

Metabolic acetate therapy improves phenotype in the tremor rat model of Canavan disease

Por Arun, Peethambaran, Madhavarao, Chikkathur N., Moffett, John R., Hamilton, Kristen, Grunberg, Neil E., Ariyannur, Prasanth S., Gahl, William A., Anikster, Yair, Mog, Steven, Hallows, William C., Denu, John M., Namboodiri, Aryan M. A.
Publicado em 2010

Intranasal Delivery of Obidoxime to the Brain Prevents Mortality and CNS Damage from Organophosphate Poisoning

Por Krishnan, Jishnu K.S., Arun, Peethambaran, Appu, Abhilash P., Vijayakumar, Nivetha, Figueiredo, Taíza H., Braga, Maria F. M., Baskota, Sudikshya, Olsen, Cara H., Farkas, Natalia, Dagata, John, Frey, William H., Moffett, John R., Namboodiri, Aryan M. A.
Publicado no Neurotoxicology (2016)