Extensive Aspartoacylase Expression in the Rat Central Nervous System

Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. Mutations in the gene for ASPA lead to reduced acetate availability in the CNS during development resulting in the fatal leukodystrophy Canavan disease. Highly specific polyclonal antibodies t...

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Bibliografiske detaljer
Main Authors: Moffett, John R., Arun, Peethambaran, Ariyannur, Prasanth S., Garbern, James, Jacobowitz, David M., Namboodiri, Aryan M.A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143213/
https://ncbi.nlm.nih.gov/pubmed/21598311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.21186
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