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The end of the road for the tryptophan depletion concept in pregnancy and infection

We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine...

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Detalhes bibliográficos
Publicado no:Clin Sci (Lond)
Main Authors: Badawy, Abdulla A.-B., Namboodiri, Aryan M.A., Moffett, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926258/
https://ncbi.nlm.nih.gov/pubmed/27358028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20160153
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